A fish swimming in water moves differently than a fish on land. This idea highlights how the environment affects behavior. A new AI tool called PINNACLE applies this concept to proteins, helping scientists understand how they work in different tissue and cell environments. Unlike existing AI models that study proteins in isolation, PINNACLE provides insights into how proteins interact with their surroundings.
Developed by Harvard Medical School researchers, PINNACLE offers more accurate protein behavior predictions, leading to safer and more effective drug designs. This tool helps scientists find new drug targets by considering the complex networks proteins form within different tissues.
PINNACLE analyzes data from 156 cell types and 62 tissues, offering richer protein insights compared to current models. This allows scientists to understand how the same protein might behave differently in various conditions, such as in healthy versus diseased cells.
By focusing on these context-specific behaviors, PINNACLE helps researchers identify more precise drug targets, improving the chances of successful treatments. With its advanced capabilities, this AI tool could speed up drug discovery, which currently takes years and costs billions.
PINNACLE’s data and findings are freely available, making it a powerful resource for scientists worldwide.
Source: harvard
